Jorge 塞拉 Fonseca

Jorge 塞拉 Fonseca的照片
Assistant Professor of Neuroscience
412-365-1511
办公室:Buhl 132 |实验室:Buhl 116

家乡:墨西哥华雷斯
加入查塔姆国际事务研究所:2021年

兴趣的学术领域
  • Fields of interest: neuroscience, cell 和 molecular biology, biochemistry, toxicology
  • 关键词:应力, 神经退化, 神经病理学, proteostasis, 信号转导, 细胞骨架
个人兴趣领域

Family, reading, cooking, gardening

传记

我出生在华雷斯市, 墨西哥, 在埃尔帕索长大, Texas-Juarez binational metropolitan area. 从小就开始, I have been fascinated by the life sciences, which is why I majored in biology at the Autonomous University of Juarez. 作为一名本科生, I had the opportunity to join a biochemistry research lab during my freshman year, where I used calcium-transporting enzymes as model systems to study the toxic effects of drugs 和 environmental pollutants. I later joined the doctoral program in pathobiology at the 德克萨斯大学埃尔帕索分校 (UTEP), where my dissertation focused on studying how intracellular signaling molecules called G proteins regulate the assembly 和 organization of the neuronal 细胞骨架, 在培养中使用神经元细胞. I later joined a 神经病理学 research lab at Harvard Medical School as a postdoctoral fellow, 我用果蝇的地方 果蝇 to study how disruption of specific cellular pathways can lead to 神经退化, a phenomenon seen in neurological disorders such as Alzheimer’s 和 Parkinson’s diseases. I later returned to UTEP for another postdoctoral appointment, where I used rodents as preclinical models to study how chronic stress can alter protein degradation pathways in the brain, how this is connected to the development of neurological disorders 和 devising potential therapeutic interventions.

教育和培训
  • 博士后,神经科学. 德克萨斯大学埃尔帕索分校, 2020
  • 博士后,神经病理学. Brigham 和 Women’s Hospital, Harvard Medical School, 2015
  • Ph.D.、病理学. 德克萨斯大学埃尔帕索分校, 2014
  • B.S.、生物学. Autonomous University of Juarez, 2007
研究

研究 at my 细胞 和 Molecular Neurobiology Lab focuses on studying chronic stress 和 its neurochemical effects on the brain. Stress is an inevitable component of our modern lifestyle, 和 it has been identified as a key factor in the development of neurodegenerative disorders. My research aims to determine how chronic stress can modify specific cellular 和 molecular pathways to predispose individuals to suffering from a neurological disorder later in life.

两者我都用 在体外 和 在活的有机体内 进行研究的方法. The SH-SY5Y neuroblastoma cell line, a widely validated model in neurobiology, is employed as a cellular model of chronic stress in combination with stress hormones. 此外，与博士合作. 凯利·洛尔(华盛顿 & Jefferson College), research in my lab uses the fruit fly, 果蝇, as a powerful genetic model to study the effects of stress on human neurodegenerative diseases (i.e.tauopathies). 除了, through ongoing collaborations derived from my postdoctoral work, rat brain tissue from chronically stressed animals is used to study the persistent effects of early-life adversity on neuronal signaling pathways.

Students interested in joining the 细胞 和 Molecular Neurobiology Lab at Chatham University should contact Dr. 塞拉.

获奖及成就
  • 玛丽年代. 以及小约翰·科斯塔洛斯. 基金会奖. 波胆网站，2022.
  • 研究 和 Sabbatical funding award. 波胆网站，2021年和2022年.
  • 维达:卡特博士后, 国家药物滥用研究所, 德克萨斯大学埃尔帕索分校, 2018-2020.
  • Academic 和 研究 Excellence Award. 德克萨斯大学埃尔帕索分校, 2014.
  • Pan American Round Table of El Paso Scholarship, 2011-2013.
  • American Society for Cell 生物学 研究生 Student Travel Award, 2012.
  • 科学学院旅游奖. 德克萨斯大学埃尔帕索分校, 2008, 2010, 和 2012.
  • 研究生 School 研究 支持 Award. 德克萨斯大学埃尔帕索分校, 2009.
  • 研究生院旅游奖. 德克萨斯大学埃尔帕索分校, 2008 和 2010.
  • 学术努力奖. Autonomous University of Juarez, 2005-2007.
社交媒体
组织
选定的出版物
  • Gosselik K.L., 塞拉-Fonseca J.A., Jezova D. (2022). Editorial: Stress, anxiety, 和 the synapse. Frontiers in Behavioral Neuroscience. http://doi.org/10.3389/fnbeh.2022.1085850
  • 哈姆丹J.N., 塞拉-Fonseca J.A., 弗洛雷斯,R.J.， Saucedo, S.M . Mir和a-Arango.O 'Dell, L.E.《波胆网站》，K.L. (2022). Early-life adversity increases anxiety-like behavior 和 modifies synaptic protein expression in a region-specific manner. Frontiers in Behavioral Neuroscience. http://doi.org/10.3389/fnbeh.2022.1008556
  • 塞拉-Fonseca J.A., 哈姆丹J.N.科恩，A.A.卡德纳斯，南卡罗来纳州.M.， Saucedo, S.洛多萨，G.A.《波胆网站》，K.L. (2021). Neonatal maternal separation modifies proteostasis marker expression in the adult hippocampus. Frontiers in Molecular Neuroscience. 14: 661993. http://doi.org/3389/fnmol.2021.661993 
  • 塞拉-Fonseca J.A., 罗德里格斯,M.塞曼，A.，里拉，欧.弗洛雷斯-拉米雷斯，F.J.巴尔加斯-梅德拉诺，J.巴拉希，G.， Iñiguez, S.D. (2021). Autophagy induction 和 accumulation of phosphorylated tau in the hippocampus 和 prefrontal cortex of adult C57BL/6 mice subjected to adolescent fluoxetine treatment. 阿尔茨海默病杂志. 83: 1691-1702. http://doi.org/3233/jad - 210475
  • Flores-Ramirez F.J.塞曼，A., 塞拉-Fonseca J.A., Garcia-Carachure,我.卡斯蒂略，南卡罗来纳州.A.罗德里格斯，M.，里拉，欧.， Preciado-Piña, J.沃伦，B.L.罗宾逊，A.J.， Iñiguez, S.D. (2021). Adolescent fluoxetine treatment mediates a persistent anxiety-like outcome in female C57BL/6 mice that is ameliorated by fluoxetine re-exposure in adulthood. 科学报告. 11: 7758. http://doi.org/10.1038/s41598-021-87378-6
  • 塞拉-Fonseca J.A., 米兰达,M.， Das, S.罗伊乔杜里，南卡罗来纳州. (2021). The bg subunit of heterotrimeric G proteins interacts with actin filaments during neuronal differentiation. Biochemical 和 Biophysical 研究 Communications. 549: 98-104. http://doi.org/10.1016/j.bbrc.2021.02.095
  • Grigoruta, M.查韦斯-索拉诺，M.瓦雷拉-拉米雷斯，A., 塞拉-Fonseca J.A., Orozco-Lucero E.哈姆丹，J.N.《波胆网站》，K.L.马丁内斯-马丁内斯，A. (2020). Maternal separation induces retinal 和 peripheral blood mononuclear cell alterations across the lifespan of female rats. 大脑研究. 1749: 147117. http://doi.org/10.1016/j.brainres.2020.147117
  • 塞拉-Fonseca J.A., 麻省理工,.F.弗洛雷斯-拉米雷斯，F.J.罗伯斯，E.H.加西亚·卡拉丘，我.， Iñiguez, S.D. (2019). Dorsal hippocampus ERK2 signaling mediates anxiolytic-related behavior in male rats. 长期的压力. 3: 1-7. http://doi.org/1177/2470547019897030
  • 塞拉-Fonseca J.A., Gosselink K.L. (2018). Tauopathy 和 神经退化: a role for stress. 应激的神经生物学. 9: 105-112. http://doi.org/10.1016/j.ynstr.2018.08.009
  • 弗洛雷斯,我.E., 塞拉-Fonseca J.A., 阿,Davalos.萨恩斯，L.A.卡斯特利亚诺斯，M.M.扎瓦拉，J.K.《波胆网站》，K.L. (2017). Stress alters the expression of cancer-related genes in the prostate. BMC癌症. 17: 621. http://doi.org/10.1186/s12885-017-3635-4
  • 塞拉-Fonseca. J.A., 阿,纳胡拉.马丁内斯-朱拉多，J.沃克，E.M.瓦雷拉-拉米雷斯，A.汗，A.M.米兰达，M.拉曼戈，n.n.S.罗伊乔杜里，南卡罗来纳州. (2014). Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gbg-microtubule interaction. BMC神经科学. 15: 3798. http://doi.org/10.1186/s12868-014-0132-4